Claire in SF wrote:
I'm not sure you can find
documented evidence that it will cause your skin to age terribly.
The opposite is more likely to be true:
Dermatol Surg. 2000 Jul;26(7):64952.
Oral isotretinoin as part of the treatment of cutaneous aging.
HernandezPerez E, Khawaja HA, Alvarez TY.
Center for Dermatology and Cosmetic Surgery, San Salvador, El
Salvador. enri...@ejje.com
BACKGROUND: A number of drugs have been used to prevent aging changes.
However, studies of oral isotretinoin, the commonly used acne drug, as
an antiaging drug are lacking.
OBJECTIVE: To determine improvement in cutaneous aging utilizing oral
isotretinoin combined with different procedures of facial rejuvenation.
METHODS: Sixty patients ranging in age from 35 to 65 years, in whom
additional modalities of rejuvenation were also used, were randomly
assigned to receive treatment with oral isotretinoin (1020 mg three
times a week for 2 months, group A). Their results were compared with 60
patients who had undergone the same surgical procedures but with no oral
isotretinoin (group B).
RESULTS: All patients treated with oral isotretinoin noted improvement
in wrinkles, thickness and color of the skin, size of pores, skin
elasticity, tone, and reduction in pigmented lesions and mottled
hyperpigmentation. A statistically significant difference was found in
the improvement of group A (Wilcoxon test <0.01). Using minimal amounts
of this drug, the side effects were practically negligible.
CONCLUSION: Utilizing various procedures with oral isotretinoin allowed
us to improve the effects of cutaneous aging. Our results using
isotretinoin in these cases have been satisfactory. We believe that this
is one of the first reports of the use of oral isotretinoin in intrinsic
and photoaged skin.
Publication Types:
* Clinical Trial
* Randomized Controlled Trial
PMID: 10886272 [PubMed indexed for MEDLINE]